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Call your healthcare provider if you have any unusual problems while taking this medication. Side Effects What are the side effects of Desloratadine (Clarinex)? Side Effects What are the side effects of Desloratadine (Clarinex)? Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Increased sleepiness or tiredness can happen if you take more Clarinex than your doctor prescribed to you Clarinex: Side Effects. Increased sleepiness or tiredness can happen if you take more Clarinex than your doctor prescribed to you Clarinex: Side Effects. Common side effects include drug ineffective among females and drug ineffective among males. Common side effects include drug ineffective among females and drug ineffective among males. 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